Marijuana Business Magazine May-June 2019

May-June 2019 | mjbizdaily.com 67 Lexaria Bioscience has 11 U.S. and international patents for DehydraTECH, a technology that uses a method of combining fatty acids such as oleic acid with an active ingredient— cannabinoids, for this purpose—to create a compound that can be used to infuse cannabis food and beverages. This is done through a dehydration processing reaction, removing water but also affecting the relationship of the molecules or compounds with each other. The result is a dry powder that can be used in anything from chocolates to beverages to capsules. Through human tissue studies and human clinical trials, the company has determined the formulation created by combining cannabinoids with fatty acids lends itself to greater shelf stability, bioabsorption and flavor, said Lexaria President John Docherty. Oleic acid is a naturally occurring and generally colorless and odorless long-chain fatty acid found in various nut and vegetable oils. It is believed to bypass receptors in the oral cavity that detect strong tastes such as bitterness, which can be a characteristic of some cannabis extracts, Docherty noted. Oleic acid is also able to pass through the intestinal wall and enter the body’s circulatory system lymphatically rather than through the liver. This increases the speed at which the oleic acid—and, in turn, the combined cannabinoids—are absorbed into the bloodstream. That translates into more rapid onset of desired effects, Docherty noted. The dehydration processing step also allows for excellent shelf stability of dried ingredients of two years and more due to the absence of all water molecules that otherwise can promote microbial growth, according to Docherty. Lexaria has used its DehydraTECH technology to develop a line of mix-and-serve tea products infused with full- spectrum hemp compounds. It also uses the same technology with nanoemulsified compounds for ready-to-serve or off- the-shelf beverages. Nanogen Labs uses nanoemulsion technology to create its nanoE liquid water-compatible solutions that can be used in ready-to-drink cannabis-infused beverages. The tiny oil droplets—ranging from 20 to 100 nanometers— are stabilized by surfactants, which are compounds that lower the surface tension between the oil droplet and the liquid. One end of the surfactant binds to water; the other binds to oil. That makes it easier for the oil to suspend itself in water rather than separate. Harold Han, Nanogen’s chief scientific officer, completed an internship with PepsiCo, where he developed emulsion formu- las for the beverage and snack giant’s flavored sodas. He also worked for Hercules, California-based Bio-Rad Laboratories, a manufacturer of products for the life science research and clini- cal diagnostics markets, where he developed emulsions to detect target DNA for diagnostics. Han said nanoemulsion technology is widely used by large food, beverage and pharmaceutical brands, which makes it easy to adapt for cannabis-infused product manufacturers. People frequently confuse nanoemulsions and nanoparti- cles. Nanoparticles have a solid core material, such as titanium dioxide, and it is difficult for the solid core to be absorbed and digested by the body. Consequently, it may stay in the body for a much longer time. Nanoemulsions, by contrast, have a liquid core and a surfac- tant layer between two liquids. As long as the liquid core and the surfactant are safe to consume, the final nanoemulsion is also safe to ingest. Han said breaking down a gram of THC oil into droplets that are 100 nanometers in diameter allows the oil to be more rapidly absorbed into the circulatory system when consumed. The emulsion formulas are stable, too, he noted. Nanogen boasts that its products won’t separate, and the droplet sizes won’t increase for more than three years, on average. In other words, the emulsion will outlast the drink or the topical in terms of shelf life. Nanogen creates different emulsion formulas for different applications. This means the emulsion formulas can be clear or cloudy and have little to no taste or retain the unique flavors of cannabinoids. “What drives us to develop different formulas is to understand how nanoemulsions can play well in different applications,” Han said. “Our formula is like a software because it’s always improving. We don’t believe that one size fits all.” LEXARIA BIOSCIENCE HEADQUARTERS Kelowna, British Columbia | EMPLOYEES 10 | FOUNDED 2004 NANOGEN LABS HEADQUARTERS Oakland, California | EMPLOYEES 10 | FOUNDED 2018