In a ruling that could adversely affect hundreds of medical marijuana businesses in Los Angeles, a three-judge panel of the state’s Second District Court of Appeals upheld a lower court ruling to block an MMJ delivery smartphone app.

The judges agreed that marijuana deliveries violate Proposition D, a voter-approved law that limits the number of medical cannabis dispensaries in Los Angeles. The ruling could provide the city with all the ammo its needs to target other MMJ delivery services in the city.

The lawsuit involved Los Angeles-based Nestdrop, which offers an app that helps medical cannabis patients order home delivery of marijuana from local dispensaries.

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Los Angeles City Attorney Michael Feuer sued NestDrop in December 2014, arguing that the company violated Prop D. The Superior Court of Los Angeles agreed, issuing an injunction ordering NestDrop to remove marijuana businesses from the app.

The company appealed, but the judges ruled that “immunity cannot accompany the marijuana when it leaves the location to be delivered elsewhere.”

Since Feuer took office, 716 medical marijuana businesses have closed across Los Angeles, according to his office.